European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
Identifieur interne : 004719 ( Main/Exploration ); précédent : 004718; suivant : 004720European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
Auteurs : Michele Baccarani [Italie] ; Michael W. Deininger [États-Unis] ; Gianantonio Rosti [Italie] ; Andreas Hochhaus [Allemagne] ; Simona Soverini [Italie] ; Jane F. Apperley [Royaume-Uni] ; Francisco Cervantes [Espagne] ; Richard E. Clark [Royaume-Uni] ; Jorge E. Cortes [États-Unis] ; François Guilhot [France] ; Henrik Hjorth-Hansen [Norvège] ; Timothy P. Hughes [Australie] ; Hagop M. Kantarjian [États-Unis] ; Dong-Wook Kim [Corée du Sud] ; Richard A. Larson [États-Unis] ; Jeffrey H. Lipton [Canada] ; François-Xavier Mahon [France] ; Giovanni Martinelli [Italie] ; Jiri Mayer [République tchèque] ; Martin C. Müller [Allemagne] ; Dietger Niederwieser [Allemagne] ; Fabrizio Pane [Italie] ; Jerald P. Radich [États-Unis] ; Philippe Rousselot [France] ; Giuseppe Saglio [Italie] ; Susanne Sau Ele [Allemagne] ; Charles Schiffer [États-Unis] ; Richard Silver [États-Unis] ; Bengt Simonsson [Suède] ; Juan-Luis Steegmann [Espagne] ; John M. Goldman [Royaume-Uni] ; Rüdiger Hehlmann [Allemagne]Source :
- Blood [ 0006-4971 ] ; 2013.
Abstract
Advances in chronic myeloid leukemia treatment, particularly regarding tyrosine kinase inhibitors, mandate regular updating of concepts and management. A European LeukemiaNet expert panel reviewed prior and new studies to update recommendations made in 2009. We recommend as initial treatment imatinib, nilotinib, or dasatinib. Response is assessed with standardized real quantitative polymerase chain reaction and/or cytogenetics at 3, 6, and 12 months. BCR-ABL1 transcript levels ≤10% at 3 months, <1% at 6 months, and ≤0.1% from 12 months onward define optimal response, whereas >10% at 6 months and >1% from 12 months onward define failure, mandating a change in treatment. Similarly, partial cytogenetic response (PCyR) at 3 months and complete cytogenetic response (CCyR) from 6 months onward define optimal response, whereas no CyR (Philadelphia chromosome–positive [Ph+] >95%) at 3 months, less than PCyR at 6 months, and less than CCyR from 12 months onward define failure. Between optimal and failure, there is an intermediate warning zone requiring more frequent monitoring. Similar definitions are provided for response to second-line therapy. Specific recommendations are made for patients in the accelerated and blastic phases, and for allogeneic stem cell transplantation. Optimal responders should continue therapy indefinitely, with careful surveillance, or they can be enrolled in controlled studies of treatment discontinuation once a deeper molecular response is achieved.
Url:
DOI: 10.1182/blood-2013-05-501569
PubMed: 23803709
PubMed Central: 4915804
Affiliations:
- Allemagne, Australie, Canada, Corée du Sud, Espagne, France, Italie, Norvège, Royaume-Uni, République tchèque, Suède, États-Unis
- Angleterre, Aquitaine, Bade-Wurtemberg, Catalogne, Communauté de Madrid, District de Karlsruhe, District de Leipzig, Grand Londres, Illinois, Michigan, Moravie, Nouvelle-Aquitaine, Ontario, Piémont, Poitou-Charentes, Région capitale de Séoul, Saxe (Land), Texas, Trøndelag, Utah, Washington (État), État de New York, Île-de-France
- Barcelone, Bordeaux, Brno, Leipzig, Londres, Madrid, Mannheim, Poitiers, Séoul, Toronto, Trondheim, Turin, Versailles
- Université Bordeaux II, Université de Poitiers, Université de Toronto
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Apperley</name><affiliation wicri:level="3"><nlm:aff id="aff5">Centre for Hematology, Imperial College, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Hematology, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name><affiliation wicri:level="3"><nlm:aff id="aff6">Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Clark, Richard E" sort="Clark, Richard E" uniqKey="Clark R" first="Richard E." last="Clark">Richard E. Clark</name><affiliation wicri:level="1"><nlm:aff id="aff7">Royal Liverpool University Hospital, Liverpool, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Liverpool University Hospital, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Cortes, Jorge E" sort="Cortes, Jorge E" uniqKey="Cortes J" first="Jorge E." last="Cortes">Jorge E. Cortes</name><affiliation wicri:level="2"><nlm:aff id="aff8">Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name><affiliation wicri:level="4"><nlm:aff id="aff9">Institut National de la Santé et de la Recherche Médicale Centres d'investigation clinique 0802, CHU de Poitiers, Université de Poitiers, Poitiers, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale Centres d'investigation clinique 0802, CHU de Poitiers, Université de Poitiers, Poitiers</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Poitou-Charentes</region><settlement type="city">Poitiers</settlement><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Hjorth Hansen, Henrik" sort="Hjorth Hansen, Henrik" uniqKey="Hjorth Hansen H" first="Henrik" last="Hjorth-Hansen">Henrik Hjorth-Hansen</name><affiliation wicri:level="3"><nlm:aff id="aff10">Department of Hematology, St. Olavs Hospital, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Hematology, St. Olavs Hospital, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Hughes, Timothy P" sort="Hughes, Timothy P" uniqKey="Hughes T" first="Timothy P." last="Hughes">Timothy P. Hughes</name><affiliation wicri:level="1"><nlm:aff id="aff11">SA Pathology and University of Adelaide, Adelaide, SA, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>SA Pathology and University of Adelaide, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name><affiliation wicri:level="2"><nlm:aff id="aff8">Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong-Wook" last="Kim">Dong-Wook Kim</name><affiliation wicri:level="3"><nlm:aff id="aff12">Department of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Larson, Richard A" sort="Larson, Richard A" uniqKey="Larson R" first="Richard A." last="Larson">Richard A. Larson</name><affiliation wicri:level="2"><nlm:aff id="aff13">The University of Chicago, Chicago, IL;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>The University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Lipton, Jeffrey H" sort="Lipton, Jeffrey H" uniqKey="Lipton J" first="Jeffrey H." last="Lipton">Jeffrey H. Lipton</name><affiliation wicri:level="4"><nlm:aff id="aff14">Princess Margaret Hospital, University of Toronto, ON, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Hospital, University of Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mahon, Francois Xavier" sort="Mahon, Francois Xavier" uniqKey="Mahon F" first="François-Xavier" last="Mahon">François-Xavier Mahon</name><affiliation wicri:level="4"><nlm:aff id="aff15">Laboratoire d’ Hématologie CHU de Bordeaux et Laboratoire Hématopoïese Leucémique et Cible Therapeutique, Université Bordeaux Ségalen, Institut National de la Santé et de la Recherche Médicale 1035, Bordeaux, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d’ Hématologie CHU de Bordeaux et Laboratoire Hématopoïese Leucémique et Cible Therapeutique, Université Bordeaux Ségalen, Institut National de la Santé et de la Recherche Médicale 1035, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name><affiliation wicri:level="3"><nlm:aff id="aff16">University Hospital Brno and Central European Institute of Technology Masaryk University, Brno, Czech Republic;</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital Brno and Central European Institute of Technology Masaryk University, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Muller, Martin C" sort="Muller, Martin C" uniqKey="Muller M" first="Martin C." last="Müller">Martin C. Müller</name><affiliation wicri:level="3"><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><affiliation wicri:level="3"><nlm:aff id="aff18">Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology and Oncology, University of Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name><affiliation wicri:level="1"><nlm:aff id="aff19">Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Napoli, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Radich, Jerald P" sort="Radich, Jerald P" uniqKey="Radich J" first="Jerald P." last="Radich">Jerald P. Radich</name><affiliation wicri:level="2"><nlm:aff id="aff20">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name><affiliation wicri:level="3"><nlm:aff id="aff21">Service d’ Hématologie et d’ Oncologie, Hôpital Mignot, Université Versailles Saint-Qentin-en-Yvelines, Versailles, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’ Hématologie et d’ Oncologie, Hôpital Mignot, Université Versailles Saint-Qentin-en-Yvelines, Versailles</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Versailles</settlement></placeName></affiliation></author><author><name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name><affiliation wicri:level="3"><nlm:aff id="aff22">Department of Oncology, University of Turin, Turin, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Sau Ele, Susanne" sort="Sau Ele, Susanne" uniqKey="Sau Ele S" first="Susanne" last="Sau Ele">Susanne Sau Ele</name><affiliation wicri:level="3"><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Schiffer, Charles" sort="Schiffer, Charles" uniqKey="Schiffer C" first="Charles" last="Schiffer">Charles Schiffer</name><affiliation wicri:level="2"><nlm:aff id="aff23">Division of Medicine and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Division of Medicine and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Silver, Richard" sort="Silver, Richard" uniqKey="Silver R" first="Richard" last="Silver">Richard Silver</name><affiliation wicri:level="2"><nlm:aff id="aff24">Weill Cornell Medical College, New York, NY;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea></affiliation></author><author><name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name><affiliation wicri:level="1"><nlm:aff id="aff25">University Hospital, Uppsala, Sweden;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>University Hospital, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Steegmann, Juan Luis" sort="Steegmann, Juan Luis" uniqKey="Steegmann J" first="Juan-Luis" last="Steegmann">Juan-Luis Steegmann</name><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff26">Servicio de Hematologia, Hospital Universitario de la Princesa, IIS-IP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Hematologia, Hospital Universitario de la Princesa, IIS-IP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Goldman, John M" sort="Goldman, John M" uniqKey="Goldman J" first="John M." last="Goldman">John M. Goldman</name><affiliation wicri:level="3"><nlm:aff id="aff27">Department of Hematology, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Hematology, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rüdiger" last="Hehlmann">Rüdiger Hehlmann</name><affiliation wicri:level="3"><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23803709</idno><idno type="pmc">4915804</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915804</idno><idno type="RBID">PMC:4915804</idno><idno type="doi">10.1182/blood-2013-05-501569</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000649</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000649</idno><idno type="wicri:Area/Pmc/Curation">000648</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000648</idno><idno type="wicri:Area/Pmc/Checkpoint">001B44</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001B44</idno><idno type="wicri:Area/Ncbi/Merge">001330</idno><idno type="wicri:Area/Ncbi/Curation">001330</idno><idno type="wicri:Area/Ncbi/Checkpoint">001330</idno><idno type="wicri:doubleKey">0006-4971:2013:Baccarani M:european:leukemianet:recommendations</idno><idno type="wicri:Area/Main/Merge">004833</idno><idno type="wicri:Area/Main/Curation">004719</idno><idno type="wicri:Area/Main/Exploration">004719</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013</title><author><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Hematology “L. and A. Seràgnoli,” S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Hematology “L. and A. Seràgnoli,” S.Orsola-Malpighi Hospital, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Deininger, Michael W" sort="Deininger, Michael W" uniqKey="Deininger M" first="Michael W." last="Deininger">Michael W. Deininger</name><affiliation wicri:level="2"><nlm:aff id="aff2">Division of Hematology and Hematologic Malignancies, University of Utah Huntsman Cancer Institute, Salt Lake City, UT;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Division of Hematology and Hematologic Malignancies, University of Utah Huntsman Cancer Institute, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Rosti, Gianantonio" sort="Rosti, Gianantonio" uniqKey="Rosti G" first="Gianantonio" last="Rosti">Gianantonio Rosti</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name><affiliation wicri:level="1"><nlm:aff id="aff4">Hematology/Oncology, Universitätsklinikum Jena, Jena, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hematology/Oncology, Universitätsklinikum Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Soverini, Simona" sort="Soverini, Simona" uniqKey="Soverini S" first="Simona" last="Soverini">Simona Soverini</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Apperley, Jane F" sort="Apperley, Jane F" uniqKey="Apperley J" first="Jane F." last="Apperley">Jane F. Apperley</name><affiliation wicri:level="3"><nlm:aff id="aff5">Centre for Hematology, Imperial College, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Hematology, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name><affiliation wicri:level="3"><nlm:aff id="aff6">Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Clark, Richard E" sort="Clark, Richard E" uniqKey="Clark R" first="Richard E." last="Clark">Richard E. Clark</name><affiliation wicri:level="1"><nlm:aff id="aff7">Royal Liverpool University Hospital, Liverpool, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Liverpool University Hospital, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Cortes, Jorge E" sort="Cortes, Jorge E" uniqKey="Cortes J" first="Jorge E." last="Cortes">Jorge E. Cortes</name><affiliation wicri:level="2"><nlm:aff id="aff8">Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name><affiliation wicri:level="4"><nlm:aff id="aff9">Institut National de la Santé et de la Recherche Médicale Centres d'investigation clinique 0802, CHU de Poitiers, Université de Poitiers, Poitiers, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale Centres d'investigation clinique 0802, CHU de Poitiers, Université de Poitiers, Poitiers</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Poitou-Charentes</region><settlement type="city">Poitiers</settlement><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Hjorth Hansen, Henrik" sort="Hjorth Hansen, Henrik" uniqKey="Hjorth Hansen H" first="Henrik" last="Hjorth-Hansen">Henrik Hjorth-Hansen</name><affiliation wicri:level="3"><nlm:aff id="aff10">Department of Hematology, St. Olavs Hospital, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway;</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Hematology, St. Olavs Hospital, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Hughes, Timothy P" sort="Hughes, Timothy P" uniqKey="Hughes T" first="Timothy P." last="Hughes">Timothy P. Hughes</name><affiliation wicri:level="1"><nlm:aff id="aff11">SA Pathology and University of Adelaide, Adelaide, SA, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>SA Pathology and University of Adelaide, Adelaide, SA</wicri:regionArea><wicri:noRegion>SA</wicri:noRegion></affiliation></author><author><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name><affiliation wicri:level="2"><nlm:aff id="aff8">Department of Leukemia, MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong-Wook" last="Kim">Dong-Wook Kim</name><affiliation wicri:level="3"><nlm:aff id="aff12">Department of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea;</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Hematology, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Larson, Richard A" sort="Larson, Richard A" uniqKey="Larson R" first="Richard A." last="Larson">Richard A. Larson</name><affiliation wicri:level="2"><nlm:aff id="aff13">The University of Chicago, Chicago, IL;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>The University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Lipton, Jeffrey H" sort="Lipton, Jeffrey H" uniqKey="Lipton J" first="Jeffrey H." last="Lipton">Jeffrey H. Lipton</name><affiliation wicri:level="4"><nlm:aff id="aff14">Princess Margaret Hospital, University of Toronto, ON, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Hospital, University of Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mahon, Francois Xavier" sort="Mahon, Francois Xavier" uniqKey="Mahon F" first="François-Xavier" last="Mahon">François-Xavier Mahon</name><affiliation wicri:level="4"><nlm:aff id="aff15">Laboratoire d’ Hématologie CHU de Bordeaux et Laboratoire Hématopoïese Leucémique et Cible Therapeutique, Université Bordeaux Ségalen, Institut National de la Santé et de la Recherche Médicale 1035, Bordeaux, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d’ Hématologie CHU de Bordeaux et Laboratoire Hématopoïese Leucémique et Cible Therapeutique, Université Bordeaux Ségalen, Institut National de la Santé et de la Recherche Médicale 1035, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna and S.Orsola-Malpighi Hospital, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name><affiliation wicri:level="3"><nlm:aff id="aff16">University Hospital Brno and Central European Institute of Technology Masaryk University, Brno, Czech Republic;</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>University Hospital Brno and Central European Institute of Technology Masaryk University, Brno</wicri:regionArea><placeName><settlement type="city">Brno</settlement><region>Moravie</region></placeName></affiliation></author><author><name sortKey="Muller, Martin C" sort="Muller, Martin C" uniqKey="Muller M" first="Martin C." last="Müller">Martin C. Müller</name><affiliation wicri:level="3"><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><affiliation wicri:level="3"><nlm:aff id="aff18">Department of Hematology and Oncology, University of Leipzig, Leipzig, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology and Oncology, University of Leipzig, Leipzig</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Leipzig</region><settlement type="city">Leipzig</settlement></placeName></affiliation></author><author><name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name><affiliation wicri:level="1"><nlm:aff id="aff19">Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Napoli, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Radich, Jerald P" sort="Radich, Jerald P" uniqKey="Radich J" first="Jerald P." last="Radich">Jerald P. Radich</name><affiliation wicri:level="2"><nlm:aff id="aff20">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name><affiliation wicri:level="3"><nlm:aff id="aff21">Service d’ Hématologie et d’ Oncologie, Hôpital Mignot, Université Versailles Saint-Qentin-en-Yvelines, Versailles, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’ Hématologie et d’ Oncologie, Hôpital Mignot, Université Versailles Saint-Qentin-en-Yvelines, Versailles</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Versailles</settlement></placeName></affiliation></author><author><name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name><affiliation wicri:level="3"><nlm:aff id="aff22">Department of Oncology, University of Turin, Turin, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Sau Ele, Susanne" sort="Sau Ele, Susanne" uniqKey="Sau Ele S" first="Susanne" last="Sau Ele">Susanne Sau Ele</name><affiliation wicri:level="3"><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Schiffer, Charles" sort="Schiffer, Charles" uniqKey="Schiffer C" first="Charles" last="Schiffer">Charles Schiffer</name><affiliation wicri:level="2"><nlm:aff id="aff23">Division of Medicine and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Division of Medicine and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Silver, Richard" sort="Silver, Richard" uniqKey="Silver R" first="Richard" last="Silver">Richard Silver</name><affiliation wicri:level="2"><nlm:aff id="aff24">Weill Cornell Medical College, New York, NY;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea></affiliation></author><author><name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name><affiliation wicri:level="1"><nlm:aff id="aff25">University Hospital, Uppsala, Sweden;</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>University Hospital, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Steegmann, Juan Luis" sort="Steegmann, Juan Luis" uniqKey="Steegmann J" first="Juan-Luis" last="Steegmann">Juan-Luis Steegmann</name><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff26">Servicio de Hematologia, Hospital Universitario de la Princesa, IIS-IP, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Hematologia, Hospital Universitario de la Princesa, IIS-IP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Goldman, John M" sort="Goldman, John M" uniqKey="Goldman J" first="John M." last="Goldman">John M. Goldman</name><affiliation wicri:level="3"><nlm:aff id="aff27">Department of Hematology, Imperial College, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Hematology, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rüdiger" last="Hehlmann">Rüdiger Hehlmann</name><affiliation wicri:level="3"><nlm:aff id="aff17">III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>III Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Advances in chronic myeloid leukemia treatment, particularly regarding tyrosine kinase inhibitors, mandate regular updating of concepts and management. A European LeukemiaNet expert panel reviewed prior and new studies to update recommendations made in 2009. We recommend as initial treatment imatinib, nilotinib, or dasatinib. Response is assessed with standardized real quantitative polymerase chain reaction and/or cytogenetics at 3, 6, and 12 months. BCR-ABL1 transcript levels ≤10% at 3 months, <1% at 6 months, and ≤0.1% from 12 months onward define optimal response, whereas >10% at 6 months and >1% from 12 months onward define failure, mandating a change in treatment. Similarly, partial cytogenetic response (PCyR) at 3 months and complete cytogenetic response (CCyR) from 6 months onward define optimal response, whereas no CyR (Philadelphia chromosome–positive [Ph+] >95%) at 3 months, less than PCyR at 6 months, and less than CCyR from 12 months onward define failure. Between optimal and failure, there is an intermediate warning zone requiring more frequent monitoring. Similar definitions are provided for response to second-line therapy. Specific recommendations are made for patients in the accelerated and blastic phases, and for allogeneic stem cell transplantation. Optimal responders should continue therapy indefinitely, with careful surveillance, or they can be enrolled in controlled studies of treatment discontinuation once a deeper molecular response is achieved.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Corée du Sud</li><li>Espagne</li><li>France</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Bade-Wurtemberg</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Karlsruhe</li><li>District de Leipzig</li><li>Grand Londres</li><li>Illinois</li><li>Michigan</li><li>Moravie</li><li>Nouvelle-Aquitaine</li><li>Ontario</li><li>Piémont</li><li>Poitou-Charentes</li><li>Région capitale de Séoul</li><li>Saxe (Land)</li><li>Texas</li><li>Trøndelag</li><li>Utah</li><li>Washington (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Bordeaux</li><li>Brno</li><li>Leipzig</li><li>Londres</li><li>Madrid</li><li>Mannheim</li><li>Poitiers</li><li>Séoul</li><li>Toronto</li><li>Trondheim</li><li>Turin</li><li>Versailles</li></settlement><orgName><li>Université Bordeaux II</li><li>Université de Poitiers</li><li>Université de Toronto</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Baccarani, Michele" sort="Baccarani, Michele" uniqKey="Baccarani M" first="Michele" last="Baccarani">Michele Baccarani</name></noRegion><name sortKey="Martinelli, Giovanni" sort="Martinelli, Giovanni" uniqKey="Martinelli G" first="Giovanni" last="Martinelli">Giovanni Martinelli</name><name sortKey="Pane, Fabrizio" sort="Pane, Fabrizio" uniqKey="Pane F" first="Fabrizio" last="Pane">Fabrizio Pane</name><name sortKey="Rosti, Gianantonio" sort="Rosti, Gianantonio" uniqKey="Rosti G" first="Gianantonio" last="Rosti">Gianantonio Rosti</name><name sortKey="Saglio, Giuseppe" sort="Saglio, Giuseppe" uniqKey="Saglio G" first="Giuseppe" last="Saglio">Giuseppe Saglio</name><name sortKey="Soverini, Simona" sort="Soverini, Simona" uniqKey="Soverini S" first="Simona" last="Soverini">Simona Soverini</name></country><country name="États-Unis"><region name="Utah"><name sortKey="Deininger, Michael W" sort="Deininger, Michael W" uniqKey="Deininger M" first="Michael W." last="Deininger">Michael W. Deininger</name></region><name sortKey="Cortes, Jorge E" sort="Cortes, Jorge E" uniqKey="Cortes J" first="Jorge E." last="Cortes">Jorge E. Cortes</name><name sortKey="Kantarjian, Hagop M" sort="Kantarjian, Hagop M" uniqKey="Kantarjian H" first="Hagop M." last="Kantarjian">Hagop M. Kantarjian</name><name sortKey="Larson, Richard A" sort="Larson, Richard A" uniqKey="Larson R" first="Richard A." last="Larson">Richard A. Larson</name><name sortKey="Radich, Jerald P" sort="Radich, Jerald P" uniqKey="Radich J" first="Jerald P." last="Radich">Jerald P. Radich</name><name sortKey="Schiffer, Charles" sort="Schiffer, Charles" uniqKey="Schiffer C" first="Charles" last="Schiffer">Charles Schiffer</name><name sortKey="Silver, Richard" sort="Silver, Richard" uniqKey="Silver R" first="Richard" last="Silver">Richard Silver</name></country><country name="Allemagne"><noRegion><name sortKey="Hochhaus, Andreas" sort="Hochhaus, Andreas" uniqKey="Hochhaus A" first="Andreas" last="Hochhaus">Andreas Hochhaus</name></noRegion><name sortKey="Hehlmann, Rudiger" sort="Hehlmann, Rudiger" uniqKey="Hehlmann R" first="Rüdiger" last="Hehlmann">Rüdiger Hehlmann</name><name sortKey="Muller, Martin C" sort="Muller, Martin C" uniqKey="Muller M" first="Martin C." last="Müller">Martin C. Müller</name><name sortKey="Niederwieser, Dietger" sort="Niederwieser, Dietger" uniqKey="Niederwieser D" first="Dietger" last="Niederwieser">Dietger Niederwieser</name><name sortKey="Sau Ele, Susanne" sort="Sau Ele, Susanne" uniqKey="Sau Ele S" first="Susanne" last="Sau Ele">Susanne Sau Ele</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Apperley, Jane F" sort="Apperley, Jane F" uniqKey="Apperley J" first="Jane F." last="Apperley">Jane F. Apperley</name></region><name sortKey="Clark, Richard E" sort="Clark, Richard E" uniqKey="Clark R" first="Richard E." last="Clark">Richard E. Clark</name><name sortKey="Goldman, John M" sort="Goldman, John M" uniqKey="Goldman J" first="John M." last="Goldman">John M. Goldman</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name></region><name sortKey="Steegmann, Juan Luis" sort="Steegmann, Juan Luis" uniqKey="Steegmann J" first="Juan-Luis" last="Steegmann">Juan-Luis Steegmann</name></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Guilhot, Francois" sort="Guilhot, Francois" uniqKey="Guilhot F" first="François" last="Guilhot">François Guilhot</name></region><name sortKey="Mahon, Francois Xavier" sort="Mahon, Francois Xavier" uniqKey="Mahon F" first="François-Xavier" last="Mahon">François-Xavier Mahon</name><name sortKey="Rousselot, Philippe" sort="Rousselot, Philippe" uniqKey="Rousselot P" first="Philippe" last="Rousselot">Philippe Rousselot</name></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Hjorth Hansen, Henrik" sort="Hjorth Hansen, Henrik" uniqKey="Hjorth Hansen H" first="Henrik" last="Hjorth-Hansen">Henrik Hjorth-Hansen</name></region></country><country name="Australie"><noRegion><name sortKey="Hughes, Timothy P" sort="Hughes, Timothy P" uniqKey="Hughes T" first="Timothy P." last="Hughes">Timothy P. Hughes</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong-Wook" last="Kim">Dong-Wook Kim</name></region></country><country name="Canada"><region name="Ontario"><name sortKey="Lipton, Jeffrey H" sort="Lipton, Jeffrey H" uniqKey="Lipton J" first="Jeffrey H." last="Lipton">Jeffrey H. Lipton</name></region></country><country name="République tchèque"><region name="Moravie"><name sortKey="Mayer, Jiri" sort="Mayer, Jiri" uniqKey="Mayer J" first="Jiri" last="Mayer">Jiri Mayer</name></region></country><country name="Suède"><noRegion><name sortKey="Simonsson, Bengt" sort="Simonsson, Bengt" uniqKey="Simonsson B" first="Bengt" last="Simonsson">Bengt Simonsson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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